All data generated or analysed during this study are included in this published article and its Supplementary Information Files. We examined this issue in a large-scale window-of-opportunity study by attempting aspiration of single dominant follicles that were found to have ruptured before a scheduled oocyte retrieval during in vitro fertilisation and embryo transfer treatment of infertile women. We were able to aspirate of 1, ultrasonographically confirmed post-rupture dominant follicles from 1, women i. These findings suggest that oocyte extrusion frequently does not occur after follicle rupture in infertile women undergoing in vitro fertilisation treatment, although the oocyte retained in the follicle can remain competent for use during that treatment. In women, Graafian dominant follicles rupture and extrude mature oocytes during ovulation. Two small-scale studies have described ruptured follicles that did not extrude their oocytes 1 , 2 , although those studies were based on experience with laparoscopic oocyte retrieval in the early s during the advent of in vitro fertilisation IVF treatment.
Prematurely ruptured dominant follicles often retain competent oocytes in infertile women
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